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ADDPLAN GmbH was founded in 2002 by Gernot Wassmer and Reinhard Eisebitt as a result of their collaboration with the aim to apply the theory of adaptive study design to clinical research. The software package 'ADDPLAN Adaptive Designs - Plans and Analyses' started as a loose collection of programmes for adaptive sample size calculation, which later were transformed uniformly into object oriented programming language and complemented by further modules for the simulation and analysis of adaptive trials. The current release ADDPLAN 5 MC comprises sample size reassessment procedures, planning and analysis issues for adaptive treatment selection multiple comparison procedures, population enrichment designs, and much more. |